Anish Kumar Mondal
My research uncovered the molecular mechanism by which the brain’s major neurotransmitter, glutamate, activates its principal receptor, the AMPA-subtype ionotropic glutamate receptor (iGluR). I demonstrated how both physiological and hyperthermic temperatures affect iGluRs. Using cryo-EM, I captured the first glutamate-activated structure of an iGluR. This discovery provides valuable insights into the molecular details of excitatory neurotransmission and offers a foundation for designing drugs targeting neurological disorders. This work was primarily conducted in Dr. Edward Twomey’s lab, in collaboration with Professor Vasanthi Jayaraman’s lab at the University of Texas Health Science Center.
Questions & Answers
Why did you choose Johns Hopkins for your work?
I chose Johns Hopkins because of its historical prestige and reputation for excellence in neuroscience and structural biology. The university’s legacy of groundbreaking research, combined with access to cutting-edge technologies like cryo-EM and a collaborative environment, made it the ideal place to pursue my work on glutamate receptors and neurological disorders.
What does receiving this award mean to you personally and professionally? Do you have any connection with the particular award you received?
It is both a personal and professional honor to be selected for this award by a committee of esteemed scientists. This recognition will undoubtedly contribute to my career advancement. I am grateful to be acknowledged
among the outstanding scientists at Johns Hopkins. Receiving an award named after Paul Ehrlich, who applied his biological expertise and understanding of basic sciences to solve translational research challenges, is truly humbling.
This recognition will inspire me to continue pursuing solutions to neurological disorders through my biophysical expertise.
What contributed to your project’s success?
The success of my project can be attributed to several key factors. First and foremost, the invaluable guidance of my postdoc mentor, Dr. Edward Twomey, whose expertise in cryo-EM data analysis and structural biology was critical.
The collaborative efforts of Dr. Elisa Carillo and Professor Vasanthi Jayaraman also played a significant role. The staff at the Beckmann Center for Cryo-EM at Johns Hopkins provided essential support for the project. Additionally, the collaborative and supportive environment in the Twomey lab contributed greatly to my progress. Lastly, my hard work and some luck helped ensure the successful completion of the project.
What thoughts do you have about Young Investigators’ Day itself, as a celebration of the roles students and fellows play in research at Johns Hopkins?
Young Investigators’ Day at Johns Hopkins is an exceptional event that showcases the remarkable work of students and fellows, providing a valuable opportunity for emerging scientists to share their research, engage in discussions and establish new collaborations. Being recognized by their institution is a significant motivator for trainees, and I feel honored to be involved in this event. It is a clear testament to Johns Hopkins’ dedication to the growth and success of its trainees.
What has been your best/most memorable experience while at Johns Hopkins?
A memorable moment for me was seeing the 2D class averages of my protein for the first time while working on cryo-EM.
What are your plans for the next year or so? Graduating, looking for faculty positions, etc.?
I am looking forward to applying for faculty positions, primarily in my home country, India.
Tell me something interesting about yourself that makes you unique. Do you have any special hobbies, interests or life experiences?
My hobby is watching cinema from around the world, and I also love playing and watching cricket.