Fan Zhao
My research established a detailed understanding of how E3 and E2 enzymes, Bre1 and Rad6, cooperatively mediate histone H2B ubiquitination, and provided insights into how cancer-associated mutations in human Bre1, Rad6 and the nucleosome disrupt this process, potentially driving cancer development. Furthermore, these findings facilitate the discovery of potential drug targets and the rational design of therapeutics for disease treatment. I did this project in Cynthia Wolberger’s Lab.
Questions & Answers
Why did you choose Johns Hopkins for your work?
Johns Hopkins not only provides a strong platform for basic research but also houses world-renowned hospitals. As is widely recognized, Johns Hopkins has made significant contributions to both basic research and clinical advancements, greatly enhancing global human health. Therefore, it serves as an exceptional platform for young investigators pursuing careers in medical science and related research fields.
What does receiving this award mean to you personally and professionally? Do you have any connection with the particular award you received?
I am deeply honored to receive this award. It inspires me to advance further in my research and plays a significant role in my career development. Being
named after the renowned biochemist Albert Lehninger, this award motivates me to pursue even more impactful work!
What contributed to your project’s success?
My Ph.D. training has provided me with strong expertise in biochemistry, equipping me to undertake this project. Additionally, guidance is crucial to its success. The Wolberger lab has decades of research experience in protein ubiquitination and epigenetics, and my mentor’s insights will be invaluable in steering this project forward.
What thoughts do you have about Young Investigators’ Day itself, as a celebration of the roles students and fellows play in research at Johns Hopkins?
I believe Young Investigators’ Day is not only a celebration of the research achievements of students and fellows at Johns Hopkins but also an opportunity to foster interdisciplinary understanding and collaboration across various research fields.
What has been your best/most memorable experience while at Johns Hopkins?
I have been deeply impressed by the incredibly supportive research environment at Johns Hopkins. When I first arrived, I had no prior experience with cryo-EM, a technique essential for the progression of my project.
However, thanks to the extensive support and training provided by the cryo- EM community, I was able to quickly develop my skills, which significantly accelerated my research progress.
What are your plans for the next year or so? Graduating, looking for faculty positions, etc.?
I still have very important projects ongoing. I will likely focus on the current research for the next few years.
Tell me something interesting about yourself that makes you unique. Do you have any special hobbies, interests or life experiences?
I often go hiking to relax. Being close to nature inspires me with new ideas.