Georgios Antonios Margonis
This study is important because it brings to the forefront surgery and tumor biology in patients with colorectal cancer liver metastases. Specifically, it is the first study to tailor surgical technique (anatomical versus non-anatomical hepatectomies) according to the presence or absence of a biomarker (wild-type versus KRAS mutated tumors). Of note, to date, the use of biomarkers was limited to only informing prognosis. The broader clinical message of the study is that because tumor biology may differ between patients with the same malignancy, surgical treatment should be individualized.