Kevin Chen


Endosomal ion homeostasis is critical for the proper function of many cells, including neurons of the central nervous system. While many neurological disorders are linked to defects in endolysosomal processing, many molecular mechanisms are still enigmatic. In Dr. Zhaozhu Qiu’s lab, I studied the proton-activated chloride (PAC) channel and its role in synaptic plasticity, which is thought to be the molecular basis of learning and memory. We discovered that PAC contributes to synaptic long-term depression (LTD), a form of plasticity that weakens synaptic connections and is important for animal physiology and behavior. This research provides evidence for a previously unexplored mechanism for synaptic plasticity along with novel approaches to study LTD.

Questions & Answers

Why did you choose Johns Hopkins for your work?

Johns Hopkins is a top research institution with experts in broad scientific fields. It also provides a uniquely collegial research environment that I could see myself thriving in.

What does receiving this award mean to you personally and professionally? Do you have any connection with the particular award you received?

I am aware of the former awardees of the Michael Shanoff Research Award, and I am humbled to be among the recipients.

What contributed to your project’s success?

I have to thank the unparalleled research community at Johns Hopkins for the success of my project. My research mentors, Drs. Rajini Rao, Richard Huganir, Seth Margolis, Shigeki Watanabe and Zhaozhu Qiu, provided crucial guidance, support and access to specific techniques that made the project successful.

 

What thoughts do you have about Young Investigators’ Day itself,  as a celebration of the roles students and fellows play in research at Johns Hopkins?

Young Investigators’ Day is an excellent way to recognize the achievements and hard work of trainees, who are often less recognized despite their direct work on the frontiers of scientific research.

What has been your best/most memorable experience while at Johns Hopkins?

I once presented a research poster at the Society for Neuroscience conference. I was really surprised with how many people stopped by my poster and the high-quality discussions I had with other scientists from around the world. It made me appreciate that science is a collective endeavor, and  that there are so many talented researchers everywhere.

What are your plans for the next year or so? Graduating, looking for faculty positions, etc.?

I will be graduating in May 2025 and will be pursuing additional research positions.

Tell  me something interesting about yourself that makes you unique. Do you have any special hobbies, interests or life experiences?

I enjoy practicing wushu at Goh’s Kung Fu in Baltimore. While completing my Ph.D. thesis, I also earned a black sash at the school and competed in several wushu competitions. It’s great exercise, and I love the people I practice with!