Minhyeok Chang
It has been known that some cells can communicate by exchanging materials through tiny bridge-like nanotubes, but whether neurons use such connections in the brain remained unknown. In this study, conducted in the lab of Dr. Hyungbae Kwon in the Department of Neuroscience, I discovered a new type of neuronal connection called dendritic nanotubes (DNTs), which form direct links between dendrites. Using advanced imaging and machine-learning analysis, we identified DNTs in mouse brains and found that they transport calcium and small molecules, including amyloid-beta (Aß), a key protein in Alzheimer’s disease. Remarkably, DNT levels increased before amyloid plaques appeared in a mouse model of Alzheimer’s, with computational simulations supporting their role in early neurodegeneration. Our findings reveal a previously unrecognized neuronal communication network in the brain, providing new insights into how neurons interact beyond synapses and potentially opening avenues for understanding and treating neurodegenerative disorders.
Questions & Answers
Why did you choose Johns Hopkins for your work?
I knew that Johns Hopkins was the best place to collaborate with leading neuroscientists and pursue this ambitious project. This study would not have been possible without the incredible researchers here who generously shared their ideas, resources and time. But most importantly, Hyungbae was here.
When others dismissed this idea as too challenging, he was the only one who saw its potential and has supported me unwaveringly to this day — I would like to express my deep appreciation for that once again.
What does receiving this award mean to you personally and professionally? Do you have any connection with the particular award you received?
This award represents a major milestone in my transition from biophysics to neuroscience as a postdoctoral researcher. After years of challenges, it feels like a recognition of my journey as an interdisciplinary scientist. It is especially meaningful to receive an award named after Paul Ehrlich, who began his research career in bioimaging — just as I did — and made a major shift to immunology at an age similar to mine when I did, where he made groundbreaking accomplishments.
What contributed to your project’s success?
My physics background was instrumental in designing my own microscope, developing novel experimental approaches, and performing computational modeling and simulations. However, I believe the key to my success was actually being an outsider to neuroscience. When I started this project, dendritic filopodia were primarily studied in the context of synapse formation, and there was no prior research exploring their role in nonsynaptic communication. Since I had never been formally trained in neuroscience, I was able to approach the problem with a fresh perspective — what some might call a “silly” but ultimately unique way of thinking.
What thoughts do you have about Young Investigators’ Day itself, as a celebration of the roles students and fellows play in research at Johns Hopkins?
Research often requires years of effort before yielding tangible results, and it is easy to lose motivation along the way — especially for trainees in an increasingly competitive environment. Young Investigators’ Day serves as a meaningful reminder of the value of our work and provides an opportunity to celebrate our contributions. It helps us reconnect with our passion for discovery and renew our commitment to the pursuit of truth.
What has been your best/most memorable experience while at Johns Hopkins?
I have so many great memories with colleagues and friends at Johns Hopkins, but if I had to choose, my most cherished experiences would be … absolutely all the free lunches I had with them at various OneNeuro seminars!
What are your plans for the next year or so? Graduating, looking for faculty positions, etc.?
I am currently preparing to establish my own independent research lab, focusing on nonsynaptic communication networks involving neurons and glia in the brain. Fingers crossed for all of us in the job market!
Tell me something interesting about yourself that makes you unique. Do you have any special hobbies, interests or life experiences?
Lately, I’ve been sharing my love of classic movies with my sons. Every weekend, we have a carefully curated family movie night featuring films I enjoyed years ago. So far, we’ve completed Star Wars, Harry Potter, The Goonies, Jurassic Park (and Jurassic World) and the extended versions of The Lord of the Rings. Unsurprisingly, our least favorites were the Star Wars sequel trilogy. I’m deeply grateful to my lovely wife and sons for all the serotonin-flourishing moments we’ve shared together.