Rong Wu
As a postdoctoral fellow in Dr. Shuying Sun’s lab in the Department of Physiology, I investigated how RNA repeats regulate RNP granule homeostasis and contribute to neurodegeneration. My research focuses on the (GGGGCC)n repeat expansion in C9ORF72, the leading genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (C9-FTD/ALS). I have demonstrated that repeat RNA disrupts nuclear speckle dynamics, sequestering SRRM2 into cytoplasmic poly-GR inclusions, which leads to RNA splicing defects and neuronal toxicity. These findings uncover a novel mechanism linking nuclear speckle dysfunction to RNA misprocessing in C9- FTD/ALS, providing insights into potential biomarkers and therapeutic targets.
Questions & Answers
Why did you choose Johns Hopkins for your work?
As a world-renowned research institution, Johns Hopkins fosters a highly collaborative and supportive environment. I was deeply drawn to the Shuying Lab’s research on RNA dysregulation in neurodegenerative diseases. Being
a member of her lab and the broader Johns Hopkins community has greatly enhanced my skills and expertise, shaping my path toward becoming an independent research scientist.
What does receiving this award mean to you personally and professionally? Do you have any connection with the particular award you received?
I am deeply honored to receive the W. Barry Wood Jr. Research Award, a truly inspiring recognition. Barry Wood’s dedication to studying disease pathogenesis closely aligns with my research interest in understanding the mechanisms of neurodegenerative diseases.
What contributed to your project’s success?
The success of my project was driven by cutting-edge research methodologies and the exploration of diverse experimental approaches. The insightful guidance of my mentor, Dr. Shuying Sun, along with productive discussions and collaborations within our research team, played a crucial role. Additionally, technical support from specialists at the Johns Hopkins University School of Medicine, as well as access to human brain samples and expert guidance from Brain Resource Core, significantly contributed to the project’s progress.
What thoughts do you have about Young Investigators’ Day itself, as a celebration of the roles students and fellows play in research at Johns Hopkins?
Young Investigators’ Day is a wonderful opportunity to recognize the achievements of researchers and celebrate the contributions of students and fellows in the basic sciences. It serves as an inspiration, encouraging the next generation of scientists to carry forward the pursuit of discovery and innovation.
What has been your best/most memorable experience while at Johns Hopkins?
My most memorable experience is the freedom to explore scientific questions and uncover answers through the development of technical methods, rigorous experimental design and systematic validation.
What are your plans for the next year or so? Graduating, looking for faculty positions, etc.?
I will pursue faculty positions to start my independent research career.
Tell me something interesting about yourself that makes you unique. Do you have any special hobbies, interests or life experiences?
I seem to be the only one in my circle who doesn’t drink coffee. In my free time, I really enjoy spending time with my family.