Yiyan Lin


Ras GTPases play a critical role in cell proliferation and differentiation and are mutated in approximately 30% of cancers. In the laboratory of Peter N. Devreotes, I investigate Ras regulation in cell migration. As Ras is activated at the leading edge of many migrating cells, my collaborator and I explored whether RasGAPs, natural Ras inhibitors, could halt migration and potentially prevent cancer metastasis. While RasGAP activation effectively suppressed Ras signaling, it unexpectedly induced cell polarization. This finding has important implications that directly inhibiting Ras may unintentionally enhance polarization and promote metastasis, highlighting careful considerations for future drug design targeting oncogenic Ras.

Questions & Answers

Why did you choose Johns Hopkins for your work?

I chose Johns Hopkins simply because of its collaborative environment for research and the supportive spirit for curiosity I received from my mentor, Peter, my department (biological chemistry) and all of my research colleagues and collaborators.

What does receiving this award mean to you personally and professionally? Do you have any connection with the particular award you received?

I am honored and humbled to receive the David Yue Award. In the spirit of perseverance, I’d like to share a quote from Dr. Yue: “You mustn’t let what

 

could have been destroy the dream and wonder of what is and what will be. Keep your bow pointed – Good luck.” May these words inspire everyone on their journey of discovery.

What contributed to your project’s success?

I am genuinely grateful for the support, advice and help I have received from my mentor, collaborators, colleagues and friends — and perhaps a little bit of luck.

What has been your best/most memorable experience while at Johns Hopkins?

All the wonderful collaborations I am fortunate to pursue with my colleagues, and the freedom to follow my passion.

What are your plans for the next year or so? Graduating, looking for faculty positions, etc.?

I plan to look for a postdoc position.