Nathan A. Zaidman
My research focuses on the role of an atypical G protein-coupled receptor (GPCR) called Gpr116. In the Pluznick lab, we are focused on how Gpr116 and other GPCRs affect kidney physiology. Recently, I discovered that Gpr116 is a significant regulator of acid excretion by the kidney. More specifically, Gpr116 acts to inhibit runaway acid secretion in A-type intercalated cells in the collecting ducts. This discovery addresses a major gap in my field’s understanding of how A-type cells regulate acid secretion. Furthermore, since Gpr116 is an atypical GPCR with some unique structural features, we can begin to form hypotheses about the biomechanical cues that may reveal how Gpr116, and other similar GPCRs, affect our physiology.